I can confirm this problem. Yesterday I received exactly this USB dongle Sonoff Zigbee 3.0 USB Dongle Plus (Model ZBDongle-E v2) and tested it on my QNAP TS-464. The dongle usually has the effect that the system can no longer shut down as described by other users and can only be switched off with the button. In addition, USB seems to be completely faulty in this state.
This also affects the connected UPS: This is no longer recognized via USB or if it is recognized, a safe shutdown can no longer be performed in the event of a power failure (as the QNAP hangs).
NAS Model: QNAP TS-464
Firmware: QTS 5.2.5.3145
USB serial drivers v. 5.0.1